The microclimate pH in poly(d,l-lactide-co-hydroxymethyl glycolide) microspheres during biodegradation
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منابع مشابه
Encapsulation of Naja –Naja Oxiana Snake venom into Poly (lactide-co-glycolide) microspheres
One small-scale double emulsion technique for incorporation of Naja- Naja oxiana venom into Poly (lactide-co-glycolide) (PLGA) microspheres were developed and optimized. The effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and In vitro release of venom were studied. A stable double emulsion was verified by homogenization method. Slow...
متن کاملBiodegradation and biocompatibility of contraceptive-steroid-loaded poly (DL-lactide-co-glycolide) injectable microspheres: in vitro and in vivo study.
PURPOSE A controlled-release drug delivery of contraceptive steroids levonorgestrel (LNG) and ethinyl estradiol (EE) has been developed by successful encapsulation of LNG and EE in poly (lactide-co-glycolide) (PLG) microspheres. MATERIALS AND METHODS Smooth, spherical, steroid-loaded PLG microspheres with a mean size of 10-25 microm were prepared by using the water/oil/water double-emulsion s...
متن کاملNew insights into the pore structure of poly(d,l-lactide-co-glycolide) microspheres.
The objective of this work was to develop a fast and significant method for the determination of the intraparticulate pore size distribution of microspheres. Poly(lactide-co-glycolide) (PLGA) microspheres prepared with a solvent extraction/evaporation process were studied. From the envelope and the skeletal volume of the microspheres the porosity was calculated. The skeletal volume was determin...
متن کاملModulation of allergic responses in mice by using biodegradable poly(lactide-co-glycolide) microspheres.
BACKGROUND Biodegradable poly(lactide- co -glycolide) (PLGA) microspheres are a promising carrier for vaccine delivery capable of maturing antigen-presenting cells to stimulate T-cell-mediated immune responses. However, the potential of microspheres to downregulate an allergic response in vivo is unknown. OBJECTIVE The aim of this study was to determine whether microspheres could potentiate D...
متن کاملPoly (lactide -co- glycolide) Fiber: An Overview
Co-polymers of lactide and glycolide, referred to as PLGA, have generated tremendous interest because of their excellent biocompatibility, biodegradability and mechanical strength. Various polymeric devices like microspheres, microcapsules, nanoparticles, pellets, implants, and films have been fabricated using these polymers. They can be transformed by spinning into filaments for subsequent fab...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2012
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2012.06.013